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Indeed, N-acetylgalactosamine-conjugated siRNA targeting AGT was highly effective in suppressing circulating AGT, thereby reducing blood pressure as ACE-inhibitors (ACE-i) and angiotensin-II receptor blockers (ARBs) (45)

5.2 Pharmacodynamic properties Glutathione (GSH) and its metabolites also interface with energetics and neurotransmitter synthesis, through several prominent metabolic pathways

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